Endocrine Abstracts

Thyroid hormone (TH) regulation of hypothalamic function has been extensively investigated. It is driven, in part, by the presence of deiodinase enzymes in tanycytes surrounding the third ventricle converting T4 to active T3. Retinoic acid (RA), the transcriptionally active form of Vitamin A, has not previously been considered to be an important part of hypothalamic regulation. Data presented here highlights novel parallels between the TH and RA synthetic...